Detection of Genetic Toxicity of 95% Acetochlor by <i>TK</i> Gene Mutation Test and Mice Micro-nucleus Test

YANG Guang-hong; LI Jun; ZHANG Ai-hua; ZHANG Xiong-fei; YAO Hui; YANG Yuan-ju

YANG Guang-hong , LI Jun , ZHANG Ai-hua , ZHANG Xiong-fei , YAO Hui , YANG Yuan-ju . Detection of Genetic Toxicity of 95% Acetochlor by TK Gene Mutation Test and Mice Micro-nucleus Test[J]. Journal of Environmental and Occupational Medicine, 2010, 27(12): 742-744.

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Detection of Genetic Toxicity of 95% Acetochlor by TK Gene Mutation Test and Mice Micro-nucleus Test

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Objective To observe the genetic toxicity of 95% acetochlor, in order to provide scientific basis for its safe use, registered pesticide management and control measures.

Methods Mutagenicity experimental models were set up. Genetic toxicity of 95% acetochlor was evaluated with TK gene mutation frequency and micronucleus rate.

Results No significant difference existed between every experimental group and negative control group for TK gene mutation frequency(P > 0.05). Compared with negative control group, the micronuleus rates of mice didn't show a statistical increase in every experimental group (P > 0.05).

Conclusion Under this experimental condition, 95% acetochlor cannot induce chromosome injury of mice polychromatic erythrocytes and gene mutation of TK6 cell.

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Detection of Genetic Toxicity of 95% Acetochlor by TK Gene Mutation Test and Mice Micro-nucleus Test

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