Objective To investigate the dynamic effects of SmCl3 on organ coefficient and anti-oxidative capacity of kidney and liver in mice.
Methods Kunming mice were randomly divided into 4 groups (30 mice in each group): blank control (0.2 mL physiological saline) group, high dose (400 mg/kg) group, moderate dose (200 mg/kg) group, and low dose (100 mg/kg) group. The mice were treated with a single intraperitoneal injection of SmCl3 or physiological saline and neutralized at the 1th, 7th, and 14th days. Organ coefficients of liver and kidney, activities of superoxide dismutase (SOD), and contents of malondialdehyde (MDA) were also measured.
Results Compared with the control group, the organ coefficient of liver in each exposure group decreased after 1d (P < 0.05 or P < 0.01), but no difference was observed after 7 d. The organ coefficient of kidney in the high dose group was higher than that of the control group after 7 d (P < 0.05). In the mice administered with SmCl3, the concentrations of MDA in liver and kidney were first decreased and then increased gradually; and the higher recovered MDA concentrations were observed, the lower SmCl3 exposures were administerted. In contrast, the activities of SOD in liver and kidney were first increased and then decreased; and the higher exposure doses were administered, the larger increases were recorded.
Conclusion Samarium could induce elevated levels of SOD and anti-oxidative capacity. Liver is more sensitive than kidney to the SOD reaction caused by SmCl3.
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