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Volume 27 Issue 8
Jun.  2017
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Abstract
QU Ai , QIU Jing-yun , HU Wen-jing . Study on the Effects of PFOS-K on the Expression of STAT3 Protein in Embryo of Mice[J]. Journal of Environmental and Occupational Medicine, 2010, 27(8): 488-490,494.
Citation: QU Ai , QIU Jing-yun , HU Wen-jing . Study on the Effects of PFOS-K on the Expression of STAT3 Protein in Embryo of Mice[J]. Journal of Environmental and Occupational Medicine, 2010, 27(8): 488-490,494.
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Study on the Effects of PFOS-K on the Expression of STAT3 Protein in Embryo of Mice

  • 1.

    School of Biology, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China


  • 2. Nation High School of Fengxian, Xuzhou, Jangsu 221700, China

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  • Received Date: February 03, 2009
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    • Abstract
  • [Objective] To study the effect of perfluorooctane sulfonate (PFOS-K)on the liver development in embryo of mice and the toxicity in the embryo.

    [Methods] PFOS-K solution with concentrations of 3mg/kg and 12 mg/kg in a cumulative dose series was infused through gavage into nine-day-pregnant mice. Then, 4 days after the treatment the expression of signal transduction and activators of transcription 3(STAT3) protein in the embryo liver were measured by immunohistochemistry.

    [Results] The expression rates of SATA3 protein in mice with dose 3 mg/kg and 12 mg/kg were 41.62% and 14.77%, respectively. The results showed significant difference (P<0.01).

    [Conclusion] The results showed that PFOS-K could affect the expression amount of STAT3 protein in the embryo liver development. It could be concluded that PFOS-K has certain damage to the liver cell in embryo of mice.

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