Objective To explore the risk factors of secondary septicemia in patients with acute leukemia(AL), followed by drug susceptibility test of related pathogens, and to provide clinical evidences for future treatment of secondary septicemia.
Methods From December 2004 to January 2010, the medical records of 73 AL cases with secondary septicemia were retrospectively reviewed. χ2 test and logistic regression models were performed to analyze 9 potential risk factors of septicemia. Drug susceptibility test was applied to isolated pathogens using disc diffusion method to examine bacterial distribution and anti-microbial resistance.
Results Totally 5 risk factors of septicemia in AL patients were identified, i.e. use of antibiotics, age, duration of hospitalization, duration of operation, and white blood cell count. The results of K-B assay indicated significant drug resistance in reviewed secondary septicemia.
Conclusion The use of antibiotics, age, length of hospital stay, duration of operation, and white blood cell count are the independent risk factors of secondary septicemia in patients with acute leukemia and therefore need strengthened management, especially on rational use of drugs.
DownLoad: