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Volume 29 Issue 11
Jun.  2017
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Abstract
WANG Yan-yan , JIANG Hong-mei , AN Yu , SHAO Xiao-cui , PIAO Feng-yuan . Influence of Arsenic Trioxide on Gene Expression Profiles of Metabolic Enzymes and Receptors for Neurotransmitters in Cerebrum of Mice[J]. Journal of Environmental and Occupational Medicine, 2012, 29(11): 671-673.
Citation: WANG Yan-yan , JIANG Hong-mei , AN Yu , SHAO Xiao-cui , PIAO Feng-yuan . Influence of Arsenic Trioxide on Gene Expression Profiles of Metabolic Enzymes and Receptors for Neurotransmitters in Cerebrum of Mice[J]. Journal of Environmental and Occupational Medicine, 2012, 29(11): 671-673.
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Influence of Arsenic Trioxide on Gene Expression Profiles of Metabolic Enzymes and Receptors for Neurotransmitters in Cerebrum of Mice

  • 1.

    Dalian Municipal Center for Disease Control and Prevention, Dalian, Liaoning, 116021, China


  • 2. Department of Occupational and Environmental Hygiene, Dalian Medical University, Dalian, Liaoning 116044, China

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  • Corresponding author:

    PIAO Feng-yuan ,Email:piaofy_dy@yahoo.com.cn

  • Received Date: October 19, 2011
    Graphical Abstract
    • Abstract
  • [Objective] To study the effect on gene expression profiles of metabolic enzymes and receptors for neurotransmitters in cerebrum of mice by chronic exposure.

    [Methods] The rats were randomly divided into three groups:4 mg/L arsenic trioxide (As2O3), 1 mg/L As2O3, and the control groups. After 60 days of exposure to As2O3 through drinking water, expressions of target genes in cerebrum of mice were studied by genechip.

    [Results] Compared to the control group, the expressions of gene Th, Dbh, Tph1, Drd3, Drd4, Adra1a, Adra2a, Adra2b, and Adrb3 of mouse cerebrum in two treated groups were statistically down-regulated, while the expressions of gene Htr1f, Htr4, and Htr7 were up-regulated.

    [Conclusion] As2O3 may down-regulate the gene expressions of neurotransmitter synthesis and catabolism enzymes and interfere with the gene expressions of partial neurotransmitter receptors in mouse cerebrum.

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