Objective To study possible mutagenic and genetic toxicity of the Artificial Cordyceps Militaris Fruitbody Water Extract (ACMFWE)and the Artificial Cordyceps Militaris Fruitbody Ethanol Extract (ACMFEE)on mice.
Methods Total of 120 mice were orally administered with ACMFWE and ACMFEE in various concentrations, micronucleus in bone marrow cells and sperm abnormalities of mice were observed; different concentrations of ACMFWE and ACMFEE were applied to in vitro mammalian cells (CHL), and the chromosome aberration was observed.
Results The bone marrow cells micronucleus rates and sperm deformity rates of mice showed no difference compared to the corresponding control groups when treated with 2.5-10.0g/kg ACMFWE or ACMFEE. With or without the metabolic activation system, the chromosome aberration rates of CHL were also found no significant difference compared to the corresponding control groups when treated with 156.0-2 500.0 μg/mL ACMFWE or ACMFEE.
Conclusion No direct or indirect mutagenesis or genetic toxicity was found in mice treated with two kinds of artificial Cordyceps fr uiting body extract in current study.
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