Objective To explore the protective effect of rhodiola rosea polysaccharide on the ultraviolet A (UVA) radiated rats.
Methods The UVA radiated rats were interfered with rhodiola rosea polysaccharides and detected for superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA) and hydroxyl radical in serum and liver homogenate to observe the role of rhodiola rosea polysaccharide in protection.
Results The serum SOD, GSH and inhibition ability of hydroxyl radical in 981.71 J/cm2 UVA group were significantly lower than that in control group (P < 0.05), but MDA in that test group was higher than that in control group (P < 0.05). In the high dose rhodiola rosea polysaccharide group, serum GSH and inhibition ability of hydroxyl radical were significantly higher than that in UVA radiation group (P < 0.05), and MDA was significantly slower than that in UVA radiation group (P < 0.05); while in the low dose rhodiola rosea polysaccharide group, MDA was obviously lower (P < 0.05) and inhibition ability of hydroxyl radical was significantly higher (P < 0.05) than that in UVA radiation group. In the liver homogenate, SOD activity and hydroxyl radical inhibition ability in UVA radiation group were significantly lower than that in control group (P < 0.05), and that in high dose rhodiola rosea polysaccharide group were significantly higher than that in UVA radiation group (P < 0.05), but MDA was obviously lower (P < 0.05).
Conclusion Rhodiola rosea polysaccharide has definite ability to repair UVA radiation damage, but its mechanism need to be further studied.
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