Objective To investigate the status of humoral immunity and cellular immunity in highway maintainance workers at highland area.
Methods A sum of 194 highway maintainance workers working at different altitudes of 2800m, 3500m, and 4 300 m were randomly sampled and investigated. Their serum content of immunoglobulin (Ig)G, A, M (g/L)were determined by immune rate scatter nephelometry, and the frequencies of CD3+, CD4+ and CD8+ T cells in peripheral blood were detected by flow cytometry.
Results Although there were no statistically significant differences in the content of IgG and IgA among the three groups (P>0.05), the content of IgM had statistically significant difference (P<0.05)among them. The frequencies of CD3+, CD4+ and CD8+ T cells also showed statistically significant differences among the three groups (P<0.01).
Conclusion Working at high altitudes area with lower concentration of oxygen in the ambient air, abnormal humoral immunity and cellular immunity were observed in highway maintainance workers.
DownLoad: