Advances of Transgenic Mouse Models in Carcinogenicity Testing

Long-term rodent carcinogenicity bioassay is widely used to evaluate carcinogenic potential of chemicals.However,relative large sample size and long test period,etc are issues hindering its application.Transgenic mouse models are applied and recognized in carcinogenicity testing.The current paper summarized common transgenic mouse models in modern carcinogenicity test assays.The advantages of transgenic mouse models may have a promising future in chemical carcinogenicity evaluation.