Objective To explore the effectiveness and safety of calcium disodium edetate (CaNa2EDTA) intravenous drip administration on childhood chronic lead poisoning.
Methods Sixty children with moderate to severe lead poisoning were admitted to a hospital and treated by CaNa2EDTA intravenous drip administration between 2006 and 2008. Blood lead levels before and after the treatment were recorded and compared. The children were observed for any side effects or abnormality related to the treatment.
Results Of the 60 patients studied, 9 cases had their blood lead level ≥ 700 μg/L, 29 cases in the range of 450-700 μg/L, and 22 cases between 250-449 μg/L. The average blood lead levels before treatment of the 3 blood-lead-level groups were (881.76& #177;141.03)μg/L, (545.47& #177;51.54)μg/L, and (389.07& #177;39.49)μg/L, respectively. After a course of treatment, the average concentrations of blood lead were (585.78& #177;115.17)μg/L, (356.97& #177;27.3)μg/L, and (213.23& #177;37.09)μg/L, respectively. No related abnormality or side effect was observed during the treatment or hospital review.
Conclusion CaNa2EDTA intravenous drip administration has been proved safe and effective in treating children moderate to severe lead poisoning.
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