Objective To study the drug rash reactions caused by NaDMPS treatment in mercury exposure cases.
Methods A retrospective analysis was carried out on 199 mercury exposure cases from 1967 through 1994, in them urine mercury concentration was elevated and drug rashes occurred after administration of NaDMPS.
Results In 20 of the 199 cases, longitudinal red spots and rashes were observed on their trunk and extremities whom were subjected to NaDMPS treatment for mercury exposure. The majority of drug rash patients ranged in ages from 19 to 30 and it was noted that the occurance rate of drug rash increased dramatically after the 4th period of NaDMPS treatment.
Conclusion Based on the study results, it should be noted that the 3rd period was crucial in the NaDMPS treatment for mercury exposure. While the 4th period of treatment is considered necessary, an interval should be rendered before it. Moreover, the occurance rate of drug rash is correlated with the augmentation of treatment and accumulation of drug doses.
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