Research progress on effect of bisphenol A on lipid metabolism

Bisphenol A (BPA), a typical environmental endocrine disruptor, is often found in daily necessities and some medical devices. In recent years, the adverse effects of BPA on lipid metabolism have aroused widespread concerns, and the results of related epidemiological studies are not completely consistent. Experimental studies have shown that BPA can induce obesity, abnormal lipid metabolism, inflammatory oxidative stress, and changes in related signal pathways and lipid metabolism genes. It is suggested that epigenetic change is the main cause of the fattening effect of BPA, and autophagy and microRNA may also play an important role. This paper summarized the reported adverse effects of BPA on lipid metabolism and expounded the related mechanisms that may be involved. The toxic mechanism of lipid accumulation caused by BPA exposure remains to be further explored in more extensive longitudinal population studies to obtain more reliable epidemiological evidence.