Research progress on circRNA and diseases
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Abstract
Circular RNA (circRNA), unlike traditional linear RNA, is a type of covalently closed circular non-coding RNA, which widely exists in organisms and often exhibits high stability, abundance, and tissue-specific expression. Its special molecular structure allows it acting as miRNA sponges, regulating transcription or splicing, and interacting with RNA binding proteins. circRNA can be used as a biomarker for the purpose of disease diagnosis. This article reviewed the formation, classification, and function of circRNA, its relationship with diseases, and the potential effects of environment and epigenetics, aiming to provide new ideas for circRNA applied in disease study, diagnosis, and treatment.
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