Relation Between Serum Total Bile Acid and Liver Function of Patients with Occupational Medicamentosalike Dermatitis Induced by Trichloroethylene

Objective To measure the fasting serum total bile acid (TBA) level of patients with occupational medicamentosa-like dermatitis induced by trichloroethylene (OMDT),and evaluate its relationship with the degree of liver damage.

Methods 106 inpatients who were diagnosed with OMDT were selected as the observation group,and 60 inpatients without OMDT and exposure to hepatotoxic chemicals were chosen as the control group.The liver function indicators of the two groups were collected for data analysis,including TBA,alanine aminotransferase (ALT),aspartate aminotransferase (AST),total protein (TP),albumin (ALB),total bilirubin (TBIL),direct bilirubin (D-BIL),gamma-glutamyl transpeptidase (GGT),total cholesterol (CHOL),and cholinesterase (CHE).

Results The inpatients with OMDT presented liver damage,with higher abnormal rates of liver function indicators than those of the control group (P<0.05).There were positive correlations between TBA and liver dysfunction grade,ALT,AST,TBIL,D-BIL,and GGT,and negative correlations between TBA and TP,ALB.The abnormal rate of TBA increased with the degree of liver dysfunction aggravating.Stratified by the degree of liver dysfunction,the abnormal rate of TBA in the mild or moderate dysfunction group was lower than that of ALT (P<0.05);there was no significant difference between the two abnormal rates in the severe dysfunction group (P>0.05);and there were no significant differences between the abnormal rates of TBA and TBIL in the groups with different degrees of liver dysfunction (P>0.05).

Conclusion Serum TBA can reflect the function of hepatocytes in OMDT patients,while the sensitivity of TBA is not as good as ALT in OMDT patients with mild or moderate liver dysfunction.However,the current conclusion derived from a retrospective study needs to be further proven.