| Citation: |
LI Jingjing, MA Mingyue, ZHANG Yan, PAN Chengyu, TIAN Ying, GAO Yu. Levels of neonicotinoid pesticides exposure and their influencing factors in 7-year-old children from Laizhou Wan Birth Cohort in Shandong, China[J]. Journal of Environmental and Occupational Medicine, 2025, 42(1): 14-21. DOI: 10.11836/JEOM24324
|
Neonicotinoid pesticides (NEOs) are widely used in agriculture and households. Previous studies have shown that populations in the Shandong region are generally exposed to NEOs, with higher environmental NEOs concentrations in Laizhou Wan due to its agricultural activities and geographical characteristics. School-aged children are vulnerable due to high food intake per body weight, warranting further investigation of their NEOs exposure in this area.
To assess the levels of NEOs exposure in 7-year-old children in the Laizhou Wan area of Shandong and to investigate dietary and sociodemographic factors that may influence their NEOs exposure levels.
Based on the Shandong Laizhou Wan Brith Cohort established from 2010 to 2013, this study included 388 children [age (7.44±0.67) years] who participated in the 7-year follow-up. The concentrations of seven NEOs [acetamiprid (ACE), imidacloprid (IMI), clothianidin (CLO), thiamethoxam (THM), thiacloprid (THD), dinotefuran (DIN), and nitenpyram (NIT)] in urine were measured using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Basic demographic information, dietary frequency, and preparation methods of fruits and vegetables were collected through questionnaires. Univariate linear regression was used to examine the associations between urinary NEOs concentrations and demographic information, dietary frequency, and preparation methods of fruits and vegetables. All β values were transformed using a formula [(2β−1)*100] to describe the percentage change (%) in urinary NEOs concentrations for each factor.
Among the 7-year-old children, the highest median creatinine-adjusted urinary concentration was for CLO (0.497 μg·g−1), followed by IMI (0.461 μg·g−1). The concentrations for DIN, THM, NIT, THD, and ACE were 0.193, 0.075, 0.013, 0.011, and 0.007 μg·g−1, respectively. The detection rates of six NEOs were above 75%, with IMI having the highest detection rate (99.74%), followed by CLO (98.71%). The univariate linear regression analysis indicated that the frequency of peeling fruits and vegetables before consumption and gender were significantly associated with urinary NEOs concentrations (P<0.05). Compared with children who peeled fruits and vegetables <1 time (per 10 times, the same hereinafter), those who peeled >3 times had 28.99% and 18.83% lower THM and ∑6NEOs concentrations, respectively. Compared to boys, girls had 23.20%–43.10% higher concentrations of ACE, IMI, THD, DIN, and ∑6NEOs. The gender-stratified analysis of dietary factors revealed that in boys, those consuming meat and eggs ≥4 times/week had 27.40% and 25.72% lower DIN and ∑6NEOs concentrations, respectively, compared to those consuming <4 times/week. Boys consuming aquatic products ≥2 times/week had 65.63% higher urinary CLO concentrations compared to those consuming <2 times/week. Compared with boys who peeled fruits and vegetables <1 times, those peeling 1–3 times had 35.11% and 22.46% lower THM and THD concentrations, and those peeling >3 times had 35.43% lower THM concentrations. These results were statistically significant (P<0.05). However, no similar associations were observed in girls.
NEOs exposure is common among the 7-year-old children in Laizhou Wan, Shandong. The frequency of peeling fruits and vegetables before consumption and gender may be influencing factors for urinary NEOs concentrations. However, further research and validation in other populations are required to confirm these findings.
| [1] |
TOMIZAWA M, CASIDA J E. NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action [J]. Annual Review of Pharmacology and Toxicology, 2005, 45(Volume 45, 2005): 247-68.
|
| [2] |
JESCHKE P, NAUEN R, SCHINDLER M, et al. Overview of the Status and Global Strategy for Neonicotinoids[J]. Journal of Agricultural and Food Chemistry, 2011, 59(7): 2897-908. doi: 10.1021/jf101303g
|
| [3] |
ZHAO Y, YANG J, REN J, et al. Exposure Level of Neonicotinoid Insecticides in the Food Chain and the Evaluation of Their Human Health Impact and Environmental Risk: An Overview[J]. Sustainability, 2020, 12(18): 7523. doi: 10.3390/su12187523
|
| [4] |
TU H, WEI X, PAN Y, et al. Neonicotinoid insecticides and their metabolites: Specimens tested, analytical methods and exposure characteristics in humans[J]. J Hazard Mater, 2023, 457: 131728. doi: 10.1016/j.jhazmat.2023.131728
|
| [5] |
LAUBSCHER B, DIEZI M, RENELLA R, et al. Multiple neonicotinoids in children's cerebro-spinal fluid, plasma, and urine[J]. Environ Health, 2022, 21(1): 10. doi: 10.1186/s12940-021-00821-z
|
| [6] |
MA X, XIONG J, LI H, et al. Long-Term Exposure to Neonicotinoid Insecticide Acetamiprid at Environmentally Relevant Concentrations Impairs Endocrine Functions in Zebrafish: Bioaccumulation, Feminization, and Transgenerational Effects[J]. Environ Sci Technol, 2022, 56(17): 12494-505. doi: 10.1021/acs.est.2c04014
|
| [7] |
ARFAT Y, MAHMOOD N, TAHIR M U, et al. Effect of imidacloprid on hepatotoxicity and nephrotoxicity in male albino mice[J]. Toxicol Rep, 2014, 1: 554-61. doi: 10.1016/j.toxrep.2014.08.004
|
| [8] |
HAWKEY A B, UNAL D, HOLLOWAY Z R, et al. Developmental exposure of zebrafish to neonicotinoid pesticides: Long-term effects on neurobehavioral function[J]. Neurotoxicology, 2023, 96: 240-53. doi: 10.1016/j.neuro.2023.05.003
|
| [9] |
TANG Z, SU Z, JIA C, et al. Neonicotinoid insecticides and metabolites levels in neonatal first urine from southern China: Exploring links to preterm birth[J]. J Hazard Mater, 2024, 469: 133910. doi: 10.1016/j.jhazmat.2024.133910
|
| [10] |
PAN C, YU J, YAO Q, et al. Prenatal neonicotinoid insecticides Exposure, oxidative Stress, and birth outcomes[J]. Environment International, 2022, 163: 107180. doi: 10.1016/j.envint.2022.107180
|
| [11] |
GUNIER R B, BRADMAN A, HARLEY K G, et al. Prenatal Residential Proximity to Agricultural Pesticide Use and IQ in 7-Year-Old Children[J]. Environ Health Perspect, 2017, 125(5): 057002. doi: 10.1289/EHP504
|
| [12] |
WANG A, WAN Y, QI W, et al. Urinary biomarkers of exposure to organophosphate, pyrethroid, neonicotinoid insecticides and oxidative stress: A repeated measurement analysis among pregnant women[J]. Sci Total Environ, 2024, 912: 169565. doi: 10.1016/j.scitotenv.2023.169565
|
| [13] |
WU X, LIU Q, LI Y, et al. Urinary neonicotinoid concentrations and obesity: A cross-sectional study among Chinese adolescents[J]. Environ Pollut, 2024, 345: 123516. doi: 10.1016/j.envpol.2024.123516
|
| [14] |
YANG Z, WANG Y, TANG C, et al. Urinary neonicotinoids and metabolites are associated with obesity risk in Chinese school children[J]. Environ Int, 2024, 183: 108366. doi: 10.1016/j.envint.2023.108366
|
| [15] |
MOYA J, BEARER C F, ETZEL R A. Children's behavior and physiology and how it affects exposure to environmental contaminants [J]. Pediatrics, 2004, 113(4 Suppl): 996-1006.
|
| [16] |
OSPINA M, WONG L Y, BAKER S E, et al. Exposure to neonicotinoid insecticides in the U. S. general population: Data from the 2015-2016 national health and nutrition examination survey[J]. Environ Res, 2019, 176: 108555. doi: 10.1016/j.envres.2019.108555
|
| [17] |
SONG S, ZHANG T, HUANG Y, et al. Urinary Metabolites of Neonicotinoid Insecticides: Levels and Recommendations for Future Biomonitoring Studies in China[J]. Environ Sci Technol, 2020, 54(13): 8210-20. doi: 10.1021/acs.est.0c01227
|
| [18] |
LIAO L, FENG S, ZHAO D, et al. Neonicotinoid insecticides in well-developed agricultural cultivation areas: Seawater occurrence, spatial-seasonal variability and ecological risks[J]. J Hazard Mater, 2024, 473: 134621. doi: 10.1016/j.jhazmat.2024.134621
|
| [19] |
SAAVEDRA J M, PRENTICE A M. Nutrition in school-age children: a rationale for revisiting priorities[J]. Nutrition Reviews, 2022, 81(7): 823-43.
|
| [20] |
ZHANG Q, LU Z, CHANG C-H, et al. Dietary risk of neonicotinoid insecticides through fruit and vegetable consumption in school-age children[J]. Environment International, 2019, 126: 672-81. doi: 10.1016/j.envint.2019.02.051
|
| [21] |
BONMATIN J M, MITCHELL E A D, GLAUSER G, et al. Residues of neonicotinoids in soil, water and people's hair: A case study from three agricultural regions of the Philippines[J]. Sci Total Environ, 2021, 757: 143822. doi: 10.1016/j.scitotenv.2020.143822
|
| [22] |
WANG H, YANG D, FANG H, et al. Predictors, sources, and health risk of exposure to neonicotinoids in Chinese school children: A biomonitoring-based study[J]. Environment International, 2020, 143: 105918. doi: 10.1016/j.envint.2020.105918
|
| [23] |
王俊东, 王依闻, 高永玲, 等. 山东莱州湾出生队列孕妇及幼儿有机磷农药暴露水平[J]. 环境与职业医学, 2018, 35(5): 423-427.
WANG J D, WANG Y W, GAO Y L, et al. Organophosphate pesticides exposure levels in pregnant women and children from Laizhou Bay Birth Cohort[J]. J Environ Occup Med, 2018, 35(5): 423-427.
|
| [24] |
何静怡, 周妍, 刘潇, 等. 育龄期男性全氟及多氟烷基化合物暴露水平及影响因素[J]. 环境与职业医学, 2023, 40(9): 989-996. doi: 10.11836/JEOM23058
HE J Y, ZHOU Y, LIU X, et al. Serum concentrations of perfluoroalkyl and polyfuoroalkyl substances and determinants in men of childbearing age[J]. J Environ Occup Med, 2023, 40(9): 989-996. doi: 10.11836/JEOM23058
|
| [25] |
ZHAO Y, ZHU Z, XIAO Q, et al. Urinary neonicotinoid insecticides in children from South China: Concentrations, profiles and influencing factors [J]. Chemosphere, 2022, 291(Pt 2): 132937.
|
| [26] |
TAO Y, DONG F, XU J, et al. Characteristics of neonicotinoid imidacloprid in urine following exposure of humans to orchards in China[J]. Environment International, 2019, 132: 105079. doi: 10.1016/j.envint.2019.105079
|
| [27] |
ZHU K, WAN Y, ZHU B, et al. Exposure to organophosphate, pyrethroid, and neonicotinoid insecticides and dyslexia: Association with oxidative stress[J]. Environ Pollut, 2024, 344: 123362. doi: 10.1016/j.envpol.2024.123362
|
| [28] |
IKENAKA Y, MIYABARA Y, ICHISE T, et al. Exposures of children to neonicotinoids in pine wilt disease control areas[J]. Environmental Toxicology and Chemistry, 2019, 38(1): 71-9. doi: 10.1002/etc.4316
|
| [29] |
LU C, CHANG C-H, PALMER C, et al. Neonicotinoid Residues in Fruits and Vegetables: An Integrated Dietary Exposure Assessment Approach[J]. Environmental Science & Technology, 2018, 52(5): 3175-84.
|
| [30] |
谭颖, 张琪, 赵成, 等. 蔬菜水果中的新烟碱类农药残留量与人群摄食暴露健康风险评价[J]. 生态毒理学报, 2016, 11(6): 67-81. doi: 10.7524/AJE.1673-5897.20160421001
TAN Y, ZHANG Q, ZHAO C, et al. Residues of neonicotinoid pesticides in vegetables and fruit and health risk assessment of human exposure via food intake[J]. Asian Journal of Ecotoxicology, 2016, 11(6): 67-81. doi: 10.7524/AJE.1673-5897.20160421001
|
| [31] |
SUR R, STORK A. Uptake, translocation and metabolism of imidacloprid in plants[J]. Bulletin of insectology, 2003, 56: 35-40.
|
| [32] |
ANDRADE G C R M, MONTEIRO S H, FRANCISCO J G, et al. Effects of Types of Washing and Peeling in Relation to Pesticide Residues in Tomatoes [J]. Journal of the Brazilian Chemical Society, 2015, 26.
|
| [33] |
XU L, XU X, WU X, et al. Sex-Dependent Environmental Health Risk Analysis of Flupyradifurone[J]. Environmental Science & Technology, 2022, 56(3): 1841-53.
|
| [1] | XIA Zhuanning, ZHANG Yan, HU Peipei, ZHAO Jiuru, LIU Zhiwei, TIAN Ying, GAO Yu. Preconceptional exposure levels and determinants of multiple pesticides among women undergoing assisted reproductive technology in Shanghai[J]. Journal of Environmental and Occupational Medicine, 2024, 41(6): 640-647. DOI: 10.11836/JEOM24025 |
| [2] | WANG Jinxia, SHI Yunhao, WANG Dongshuai, DONG Xuehao, ZHANG Hanqing, ZHOU Sijie, ZHAO Yi, ZHANG Yuhong, ZHANG Yajuan. Effects of long-term exposure to ambient fine particulate matter on diabetes mellitus and the moderating effects of diet[J]. Journal of Environmental and Occupational Medicine, 2024, 41(3): 259-266. DOI: 10.11836/JEOM23194 |
| [3] | WANG Lu, LIANG Qi, QIN Shuxia. Relationships between dietary habits and blood pressure in employees of a chemical enterprise in Gansu Province[J]. Journal of Environmental and Occupational Medicine, 2023, 40(9): 1052-1057. DOI: 10.11836/JEOM23085 |
| [4] | ZHANG Meiru, YAO Jiahui, SONG Rui, XU Dong. Dietary exposure level of to perfluorinated compounds and its relationship with perinatal adverse events in pregnant women in Xuhui District of Shanghai[J]. Journal of Environmental and Occupational Medicine, 2023, 40(7): 796-804. DOI: 10.11836/JEOM22396 |
| [5] | ZHANG Hanqing, ZHOU Sijie, WANG Jinxia, SHI Yunhao, ZHAO Yi, ZHANG Yuhong, ZHANG Yajuan. Effects of long-term exposure to ambient PM2.5 on hypertension and role of dietary regulation[J]. Journal of Environmental and Occupational Medicine, 2023, 40(5): 551-558. DOI: 10.11836/JEOM22364 |
| [6] | WU Chun-feng, LUO Bao-zhang, ZHU Zhen-ni, LIU Hong, FANG Ya-min, YU Hui-ting, ZOU Shurong, GUO Chang-yi, WU Fan. Assessment of Dietary Exposure Level of Aluminum in Residents Aged 15 Years or Above in Shanghai[J]. Journal of Environmental and Occupational Medicine, 2016, 33(6): 529-535. DOI: 10.13213/j.cnki.jeom.2016.16270 |
| [7] | CHEN Li-mei , ZHANG Xiu-hong , WANG Qian , CUI Chang , DING Guo-dong , WANG Cai-feng , GAO Yu , TIAN Ying . Levels and Dietary Factors of Minerals in Maternal and Cord Serum in an Area of Shandong Province[J]. Journal of Environmental and Occupational Medicine, 2015, 32(8): 722-727. DOI: 10.13213/j.cnki.jeom.2015.14616 |
| [8] | TANG Hong-mei , FANG Hong , DING Ke-ying , LIU Yi-nan , CAO Li-li , YAN Yu-jie , XU Hui-lin , ZHANG Jin-ling , WANG Wei-jie , ZHOU Jie . Dietary Behavior and Impact Factors among Students in Primary and Middle Schools in Minhang District, Shanghai[J]. Journal of Environmental and Occupational Medicine, 2013, 30(5): 328-332. |
| [9] | LIU Hong , WU Chun-feng , LU Yi , FANG Ya-min . Dietary Cadmium Exposure Assessment in Shanghai Adult Residents[J]. Journal of Environmental and Occupational Medicine, 2010, 27(12): 711-715. |
| [10] | WANG Hua , DU Gang , WANG Jing . Dietary Habit and Nutritional Survey among Freshmen of a College in He-bei[J]. Journal of Environmental and Occupational Medicine, 2010, 27(7): 435-436,440. |
| 1. |
卜千，贾乐乐，李静芸，张忠彬. 工作场所手传振动作业健康风险管理现状与问题探讨. 中华劳动卫生职业病杂志. 2024(01): 69-72 .
| |
| 2. |
潘思玉，严茂胜，肖斌，贾艳霞，郑浛君，蒋雍建，林瀚生，王梅. 手持工件打磨作业致职业性手臂振动病流行病学调查. 中国职业医学. 2024(01): 65-69 .
| |
| 3. |
吴思恒，陈青松，曾颖珊，夏云，杨虹雨. 振动诱导体外血管内皮细胞铁含量、脂质过氧化及铁死亡相关基因表达的改变. 环境与职业医学. 2024(05): 560-566 .
本站查看
| |
| 4. |
朱文杰，王谦可，凌灵，欧阳燕芬，吴秀娟，邱奕冰. 佛山市顺德区手传振动作业工人职业健康检查结果分析. 职业与健康. 2024(11): 1549-1552 .
| |
| 5. |
梁灿坤，汤永翔，梁锦梅，李燕茹，宋慧东，王致. 手传振动接触水平与白细胞系指标和代谢综合征的关联性分析. 中国工业医学杂志. 2024(05): 447-451+486 .
| |
| 6. |
蒋柳权，黄惠民，张永雷，杨帆，赵敏，赵宏霞，刘改生，陈青松. 工作场所手传振动测量存在问题及对策. 工业卫生与职业病. 2024(06): 541-542+547 .
|
Supported by: Beijing Renhe Information Technology Co., Ltd. 
DownLoad: