Relationship of hypertension with interactions among <i>ABCA1</i> gene, <i>AGT</i> gene, and occupational stress

FU Ailing; LI Xinze; LIU Xin; LIU Jiwen

doi:10.11836/JEOM22138

Volume 39 Issue 10

Feb. 2023

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Journal of Environmental and Occupational Medicine > 2022 > 39(10): 1115-1121. > DOI: 10.11836/JEOM22138

FU Ailing, LI Xinze, LIU Xin, LIU Jiwen. Relationship of hypertension with interactions among ABCA1 gene, AGT gene, and occupational stress[J]. Journal of Environmental and Occupational Medicine, 2022, 39(10): 1115-1121. DOI: 10.11836/JEOM22138

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Relationship of hypertension with interactions among ABCA1 gene, AGT gene, and occupational stress

FU Ailing^{1, 2,},
LI Xinze¹,
LIU Xin¹,
LIU Jiwen^1, ,

1.
School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 830011, China
2.
Medical Record Management Department, The Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, China

Funds: This study was funded.

More Information

Corresponding author:
LIU Jiwen, E-mail: liujiwendr@163.com
Received Date: April 12, 2022
Accepted Date: August 15, 2022
Available Online: February 14, 2023

Graphical Abstract

Abstract

Abstract

Background
Hypertension is influenced by both genes and environment. At present, most studies on the relationship among occupational stress, polymorphisms of ATP binding cassette subfamily A member 1 (ABCA1) or angiotensinogen (AGT) genes, and hypertension focus on single gene or single environmental effects.
Objective
To investigate the relationship of potential interactions between ABCA1 and AGT gene polymorphisms and occupational stress with the prevalence of hypertension.
Methods
A total of 198 hypertensive patients were selected as the case group from the 1200 oilfield workers in Karamay Oilfield in 2018 with random cluster sampling method, and the control group was selected as 1∶1 matched subjects for sex, age (±3 years), and ethnicity, after excluding blood samples, questionnaires, or DNA purity (concentration) that did not meet the inclusion criteria. Finally, 153 workers in the hypertension case group and 153 workers in the control group were determined. A questionnaire was used to collect general information of the oilfield workers, and the Occupational Stress Inventory Revised Edition (OSI-R) was used to evaluate occupational stress. Polymerase chain reaction-restriction fragment length polymorphism technology was used to detect the genotypes of V825I and R219K loci of ABCA1 as well as M235T and T174M loci of AGT. The gene-gene interaction of ABCA1 and AGT and the relationship between the interaction of gene-occupational stress and the prevalence of hypertension were analyzed by generalized multi-factor dimensionality reduction method.
Results
The difference of reported occupational stress between the hypertension case group and the control group was statistically significant (P＝0.001), and the reporting rate of high occupational stress in the case group (65.4%) was higher than that in the control group (47.7%). The genotype and allele distributions of ABCA1 V825I, ABCA1 R219K, and AGT M235T between the hypertension case group and the control group were significantly different (P<0.05). The results of conditional logistic regression analysis showed that VI and II genotypes at V825I locus of ABCA1 (OR_VI=1.682, 95%CI: 1.099-2.573; OR_II=1.708, 95%CI: 1.045-2.790), TT genotype at M235T locus of AGT (OR=1.645, 95%CI: 1.022-2.647), and high occupational stress (OR=2.642, 95%CI: 1.228-5.686) increased the risks for hypertension (P<0.05). There was no significant correlation between ABCA1 R219K or AGT T174M polymorphisms and the prevalence of hypertension (P>0.05). The gene-gene interactions between ABCA1 V825I and R219K loci and AGT M235T locus were associated with hypertension (accuracy on training and test sets was 0.68 and 0.63, respectively, with a cross-validation coefficient of 10/10, P<0.05), and ABCA1 V825I locus positively interacted with AGT M235T locus. The gene-environment interactions among ABCA1 V825I and R219K loci, AGT M235T locus, and occupational stress were associated with hypertension (accuracy on training and test sets was 0.74 and 0.63, respectively, with a cross-validation coefficient of 10/10, P<0.05), and AGT M235T locus negatively interacted with occupational stress.
Conclusion
Genotype VI and II of V825I locus at ABCA1, genotype TT of M235T locus at AGT, and high occupational stress may be risk factors for oilfield workers’ hypertension in Karamay, and the interactions of gene-gene and gene-environment among ABCA1 and AGT gene polymorphisms and occupational stress may be associated with hypertension.
- occupational stress,
- gene polymorphism,
- interaction,
- hypertension

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References (25)

References

[1]	LAMIRAULT G, ARTIFONI M, DANIEL M, et al. Resistant hypertension: novel insights[J]. Curr Hypertens Rev, 2020, 16(1): 61-72. doi: 10.2174/1573402115666191011111402
[2]	SCHREINER P, BIEDERMANN L, ROSSEL J B, et al. Prevalence and determinants of job stress in patients with inflammatory bowel disease[J]. Inflamm Bowel Dis, 2017, 23(2): 310-317. doi: 10.1097/MIB.0000000000001012
[3]	RUGULIES R, FRAMKE E, SØRENSEN J K, et al. Persistent and changing job strain and risk of coronary heart disease. A population-based cohort study of 1.6 million employees in Denmark[J]. Scand J Work Environ Health, 2020, 46(5): 498-507. doi: 10.5271/sjweh.3891
[4]	LANDSBERGIS P A, DOBSON M, KOUTSOURAS G, et al. Job strain and ambulatory blood pressure: a meta-analysis and systematic review[J]. Am J Public Health, 2013, 103(3): e61-e71. doi: 10.2105/AJPH.2012.301153
[5]	YONG X, GAO X, ZHANG Z, et al. Associations of occupational stress with job burn-out, depression and hypertension in coal miners of Xinjiang, China: a cross-sectional study[J]. BMJ Open, 2020, 10(7): e036087. doi: 10.1136/bmjopen-2019-036087
[6]	BABASHAMSI M M, KOUKHALOO S Z, HALALKHOR S, et al. ABCA1 and metabolic syndrome; a review of the ABCA1 role in HDL-VLDL production, insulin-glucose homeostasis, inflammation and obesity[J]. Diabetes Metab Syndr:Clin Res Rev, 2019, 13(2): 1529-1534. doi: 10.1016/j.dsx.2019.03.004
[7]	何春燕, 陈潇潇, 冯程, 等. HIV/AIDS患者静息心率和血脂异常与正常高值血压/高血压的关联[J]. 中华疾病控制杂志, 2021, 25(12): 1387-1392,1397. doi: 10.16462/j.cnki.zhjbkz.2021.12.005 HE C Y, CHEN X X, FENG C, et al. Associations of resting heart rate and dyslipidemia with prehypertension and hypertension among HIV/AIDS patients[J]. Chin J Dis Control Prev, 2021, 25(12): 1387-1392,1397. doi: 10.16462/j.cnki.zhjbkz.2021.12.005
[8]	BIGAZZI R, ZAGATO L, LANZANI C, et al. Hypertension in high school students: genetic and environmental factors: the HYGEF study[J]. Hypertension, 2020, 75(1): 71-78. doi: 10.1161/HYPERTENSIONAHA.119.13818
[9]	YATES J D, ALDOUS J W F, BAILEY D P, et al. The prevalence and predictors of hypertension and the metabolic syndrome in police personnel[J]. Int J Environ Res Public Health, 2021, 18(13): 6728. doi: 10.3390/ijerph18136728
[10]	XU Z, ZHANG D, LIN J, et al. The influence of CYP2R1 polymorphisms and gene-obesity interaction with hypertension risk in a Chinese rural population[J]. Nutr Metab Cardiovasc Dis, 2022, 32(1): 241-248. doi: 10.1016/j.numecd.2021.11.003
[11]	付爱玲, 陶宁, 葛华, 等. 克拉玛依油田工人职业紧张与ADD1基因对高血压患病率的影响[J]. 环境与职业医学, 2018, 35(3): 203-208. FU A L, TAO N, GE H, et al. Effects of occupational stress and ADD1 gene on prevalence of hypertension in Karamay oilfield workers[J]. J Environ Occup Med, 2018, 35(3): 203-208.
[12]	中国高血压防治指南修订委员会, 高血压联盟, 中华医学会心血管病学分会中国医师协会高血压专业委员会, 等. 中国高血压防治指南(2018年修订版)[J]. 中国心血管杂志, 2019, 24(1): 24-56. doi: 10.3969/j.issn.1007-5410.2019.01.002 Writing Group of 2018 Chinese Guidelines for the Management of Hypertension, Hypertension Committee of Chinese Medical Association. Hypertension Alliance, Chinese Medical Association. Cardiovascular Branch, et al. 2018 Chinese guidelines for the management of hypertension writing group of 2018[J]. Chin J Cardiovasc Med, 2019, 24(1): 24-56. doi: 10.3969/j.issn.1007-5410.2019.01.002
[13]	冯聪蕊, 张伟丽. 广义多因素降维法在心脑血管病基因-基因/环境交互作用分析及风险预测中的应用[J]. 中国医学前沿杂志(电子版), 2017, 9(10): 47-52. FENG C R, ZHANG W L. Application of the generalized multifactor dimensionality reduction (GMDR) method in the gene-by-gene and gene-by-environment interactions and cardiovascular risk prediction[J]. Chin J Front Med Sci(Electron Vers), 2017, 9(10): 47-52.
[14]	ZHAO X, REN Y, LI H, et al. Association of LIPC -250G/A and -514C/T polymorphisms and hypertension: a systematic review and meta-analysis[J]. Lipids Health Dis, 2018, 17(1): 238. doi: 10.1186/s12944-018-0884-4
[15]	SIONAKIDIS A, MCCALLUM L, PADMANABHAN S. Unravelling the tangled web of hypertension and cancer[J]. Clin Sci (Lond), 2021, 135(13): 1609-1625. doi: 10.1042/CS20200307
[16]	JOHNSON R J, BAKRIS G L, BORGHI C, et al. Hyperuricemia, acute and chronic kidney disease, hypertension, and cardiovascular disease: report of a scientific workshop organized by the national kidney foundation[J]. Am J Kidney Dis, 2018, 71(6): 851-865. doi: 10.1053/j.ajkd.2017.12.009
[17]	JIANG Y, CUI C, GE H, et al. Effect of 5-HT2A receptor polymorphisms and occupational stress on self-reported sleep quality: a cross-sectional study in Xinjiang, China[J]. Sleep Med, 2016, 20: 30-36. doi: 10.1016/j.sleep.2015.12.007
[18]	杨博. ABCA1基因rs363717与冠心病易感性的关联研究[J]. 天津中医药大学学报, 2019, 38(4): 364-368. YANG B. The studies of the association between ABCA1 gene rs363717 with blood lipids and coronary heart disease susceptibility[J]. J Tianjin Univ Tradit Chin Med, 2019, 38(4): 364-368.
[19]	薛偕华, 黄赛娥, 吴加勇, 等. ABCA1基因V825I多态性与腔隙性脑梗死合并高血压病的相关性研究[J]. 中西医结合心脑血管病杂志, 2012, 10(2): 163-165. doi: 10.3969/j.issn.1672-1349.2012.02.022 XUE X H, HUANG S E, WU J Y, et al. Correlation between ABCA1 gene V825I polymorphism and lacunar cerebral infarction complicated with hypertension[J]. Chin J Integr Med Cardio Cerebrovasc Dis, 2012, 10(2): 163-165. doi: 10.3969/j.issn.1672-1349.2012.02.022
[20]	洪雄新, 李观强, 杨辉, 等. 2型糖尿病患者ABCA1 R219K基因多态性分布及其与血脂水平的相关性研究[J]. 现代检验医学杂志, 2020, 35(4): 14-17. doi: 10.3969/j.issn.1671-7414.2020.04.004 HONG X X, LI G Q, YANG H, et al. Study on distribution of ABCA1 R219K gene polymorphism and its correlation with blood lipid levels for type 2 diabetes mellitus patients[J]. J Mod Lab Med, 2020, 35(4): 14-17. doi: 10.3969/j.issn.1671-7414.2020.04.004
[21]	张红艳, 孙雪文, 张志涛. AGT基因M235T多态性与原发性高血压靶器官损伤的关系研究[J]. 现代预防医学, 2014, 41(5): 891-893. ZHANG H Y, SUN X W, ZHANG Z T. Study of association of AGT gene M235T polymorphism with target organ damage in primary hypertension patients[J]. Mod Prev Med, 2014, 41(5): 891-893.
[22]	李星辉, 侯彦军, 马光荣, 等. 血管紧张素原基因M235T、T174M多态性与东乡族人群原发性高血压的相关性[J]. 兰州大学学报(医学版), 2021, 47(4): 19-23,29. doi: 10.13885/j.issn.1000-2812.2021.04.004 LI X H, HOU Y J, MA G R, et al. Relationship between the gene polymorphism of angiotens-inogen gene M235T and T174M mutation and essential hypertension in Dongxiang population[J]. J Lanzhou Univ (Med Sci), 2021, 47(4): 19-23,29. doi: 10.13885/j.issn.1000-2812.2021.04.004
[23]	KOLOVOU V, LAGOU E, MIHAS C, et al. Angiotensinogen (AGT) M235T, AGT T174M and angiotensin-1-converting enzyme (ACE) I/D gene polymorphisms in essential hypertension: effects on ramipril efficacy[J]. Open Cardiovasc Med J, 2015, 9: 118-126. doi: 10.2174/1874192401509010118
[24]	隋小芳, 咸爽, 崔国利, 等. H型高血压患者血尿酸与脂代谢的关系研究[J]. 中国实验诊断学, 2022, 26(1): 45-48. doi: 10.3969/j.issn.1007-4287.2022.01.015 SUI X F, XIAN S, CUI G L, et al. Study on the relationship between serum uric acid and lipid metabolism in patients with H-type hypertension[J]. Chin J Lab Diagn, 2022, 26(1): 45-48. doi: 10.3969/j.issn.1007-4287.2022.01.015
[25]	胡柯, 陈月富, 金玲, 等. 候选基因多态性与饮食习惯的交互作用对武陵山片区H型高血压患病的影响研究[J]. 中国预防医学杂志, 2021, 22(5): 349-355. doi: 10.16506/j.1009-6639.2021.05.005 HU K, CHEN Y F, JIN L, et al. The association between candidate gene polymorphism together with dietary habits and H-type hypertension in Wuling Mountainous area[J]. Chin Prev Med, 2021, 22(5): 349-355. doi: 10.16506/j.1009-6639.2021.05.005