Research progress of circRNA in silicosis fibrosis
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Graphical Abstract
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Abstract
Silicosis is a chronic progressive pulmonary fibrosis disease that seriously endangers the occupational health of workers. There is no effective treatment at present. It is urgent to find effective therapeutic targets and use molecular markers to intervene the process of silicosis fibrosis. As a new type of non-coding RNA, circular RNA (circRNA) has the characteristics of stable structure, long half-life, high conservation, and is specifically expressed in different species, tissues, diseases, and developmental stages, and has potential value and application prospects as a biomarker. In recent years, the regulatory role of circRNA in the occurrence and development of human diseases has become a research hotspot. Some circRNAs have been found to associate with the pathogenesis of silicosis. This article briefly described the biological characteristics and functions of circRNA, focused on the reported relationship between circRNA and pathogenesis of silicosis, summarized the current research progress of circRNA-mediated pathogenesis of silicosis, and then put forward potential directions and suggestions for further research on targeting circRNA in the diagnosis and treatment of silicotic fibrosis.
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