新生儿胎粪中环境内分泌干扰物含量与低出生体重的关联

赵岩; 林玲; 张蕴晖; 陈丽; 顾曰萍; 郑力行

新生儿胎粪中环境内分泌干扰物含量与低出生体重的关联

1.
复旦大学公共卫生安全教育部重点实验室, 上海 200032
2. 长宁区妇幼保健院, 上海 200051
3. 复旦大学公共卫生学院卫生化学教研室, 上海 200032

基金项目: 上海市自然基金项目(编号:10ZR1402000)

详细信息

作者简介:
赵岩(1986-),男,硕士生;研究方向:儿童环境卫生学,E-mail:10211020021@fudan.edu.cn

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出版历程
- 收稿日期: 2010-10-01
- 刊出日期: 2017-07-18

Correlation between the Level of Environmental Endocrine Disruptors in Meconium of Newborns and Low Birth Weight

1.
Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China
2. Changning Maternity and Infant Health Hospital, Shanghai 200051, China
3. Department of Sanitary Chemistry, School of Public Health, Fudan University, Shanghai 200032, China

摘要

摘要:
[目的] 研究新生儿胎粪中环境内分泌干扰物(EDs)的含量,并探讨其与新生儿低出生体重间的关联。

[方法] 上海市某区2006-2007年间出生的新生儿,病例组为88例低出生体重新生儿,对照组为113例正常新生儿。在新生儿娩出后24 h内,收集所有胎粪,采用反相高效液相色谱法(RP-HPLC)测定其5种目标EDs,即双酚A(BPA)、邻苯二甲酸单丁酯(MBP)、邻苯二甲酸单乙基己酯(MEHP)、辛基酚(OP)和壬基酚(4-NP)的含量水平,并分析新生儿胎粪中EDs含量与低出生体重间的相关性,校正混杂因素后评估其健康风险。

[结果] 超过60%的新生儿胎粪样本均检测到上述5种目标EDs,其中邻苯二甲酸单酯类(MBP和MEHP)的含量高于BPA和表面活性剂类(OP和4-NP);对照组胎粪中的EDs平均含量明显低于病例组。胎粪中MBP和MEHP的含量与新生儿出生体重的降低呈正相关,校正OR值分别达到4.68和3.23。

[结论] 作为两种常见的EDs,增塑剂(双酚A和邻苯二甲酸酯类)和表面活性剂类在新生儿胎粪中被普遍检出;且宫内期暴露于这些EDs,可能会增加新生儿低出生体重的风险。
- 低出生体重 /
- 胎粪 /
- 环境内分泌干扰物 /
- 反相高效液相色谱
Abstract:
[Objective] To measure the contents of environmental endocrine disruptors (EDs) in the meconium of newborns,and to study the correlation between EDs levels and low birth weight (LBW).

[Methods] A total of 88 low-birth-weight newborns and 113 normal birth weight newborns in a district of Shanghai were enrolled in this case-control study.During 24h after delivery,meconium samples of newborns were collected and pretreated with C18-solid phase extraction (SPE) column.The concentrations of bisphenol A (BPA),phthalate metabolites (mono-2-ethylhexyl phthalate,MEHP;monobutyl phthalate,MBP) and two kinds of surfactants (4-nonylphenol,4-NP;octylphenol,OP) in meconium samples were measured by reversed-phase high performance liquid chromatography.Pearson correlation and conditional logistic regression were used to analyze the correlation between EDs exposure and LBW.

[Results] More than 60% of the meconium samples contained quantifiable levels of phthalates and surfactants,with higher levels in the LBW newborns than in the controls.MEHP and MBP levels were higher than BPA and surfactants.After adjusting for the potential confounders,MBP and MEHP concentrations in the highest quartile were associated with an increased risk of LBW (Adjusted ORs were 4.68 and 3.23,respectively).

[Conclusion] Newborns are ubiquitously exposed to EDs for significantly higher phthalate levels are detected in the LBW cases compared with the controls.Intrauterine phthalate exposure may be a risk factor for LBW.
- low birth weight /
- meconium /
- environmental endocrine disrupters /
- reversed-phased high performance liquid chromatography

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