Abstract:
Environmental responsive gene pregnane X receptor (PXR) is one of the most important nuclear receptors that acts as both a "sensor" and an "effector" regulating glucose metabolism, drug resistance, and inflammation. So far, it is well-established that PXR transcriptionally regulate the expression of some CYP450 enzymes; however, PXR-mediated protein-protein interaction unraveled PXR's novel functions beyond transcriptional regulation. In this article, we reviewed some interactions that occurred between PXR and critical proteins in epigenetic modifications, such as the interactions of PXR with methyltransferases, acetyltransferases, and ubiquitin and SUMO (small ubiquitin-related modifier) ligases, which may help us better understand the role of PXR in cellular stress and clarify the mechanisms of environmental responsive genes regulating biotic events.