Abstract:
Cerium oxide nanoparticles (CeO
2NPs) are a kind of widely used nanometer rare earth metal oxide. Experimental studies show that CeO
2NPs have a similar antioxidant activity with superoxide dismutase and catalase, help to alleviate or reduce inflammation, and produce an anti-inflammatory effect. At the same time, CeO
2NPs have an inflammatory effect by inducing oxidative stress and then cell toxicity. This paper summarized the relationship between inflammation and CeO
2NPs at different concentrations, through different intake pathways, and with different particle sizes:CeO
2NPs are prone to have an inflammatory effect with a higher concentration
in vivo; the intake pathways determine where the particles accumulate; and CeO
2NPs are prone to have an anti-inflammatory effect with smaller sizes.