大气PM2.5对心血管系统损伤机制的研究进展
Review on mechanisms of PM2.5 in cardiovascular system injuries
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摘要:
大气污染是我国公共卫生领域的一项重大挑战。细颗粒物(PM2.5)作为大气颗粒物中的主要污染成分,与心血管疾病的发生发展密切相关。故本文拟从氧化应激、炎症反应、DNA甲基化、DNA损伤、细胞凋亡、血管内皮功能紊乱的角度展开,结合相关体内、体外实验研究,综合探讨并总结PM2.5暴露在心血管疾病发生发展中的作用及其机制。
Abstract:Air pollution is a major challenge to public health in China. Fine particulate matter (PM2.5), a key component of atmospheric pollutants, is closely related to the occurrence and development of cardiovascular diseases. Therefore, based on existing
in vivo andin vitro studies, this review elucidated the potential mechanisms of PM2.5 exposure in the pathogenesis of cardiovascular diseases from the following aspects:oxidative stress, inflammation, DNA methylation, DNA damage, apoptosis, and vascular endothelial dysfunction.