金属离子诱导帕金森病的研究进展

Research progress on metal ion-induced Parkinson's disease

摘要:
帕金森病（PD）是神经退行性疾病的研究热点之一，其发病机制尚存在争议。微量金属元素在人体正常生长发育中发挥重要的作用，金属离子会穿过血脑屏障进入大脑导致α-突触核蛋白聚集、线粒体功能破坏并导致多巴胺能神经元变性，继而诱发PD的发生。本文主要回顾了不同金属元素对PD影响的作用机制以及探讨了人体内常见微量金属铜、铁、锰、锌代谢失衡在PD中的作用，并为PD的治疗提出新见解。

Abstract:
Parkinson's disease (PD) is one of the hotspots in the research field of neurodegenerative diseases, and its pathogenesis is still controversial. Trace metal elements play an important role in normal growth and development of the human body. Metal ions can cross the blood-brain barrier and enter the brain, leading to α-synapnuclein aggregation, mitochondrial dysfunction, and degeneration of dopaminergic neurons, and then inducing the occurrence of PD. This article mainly reviewed the potential mechanisms of metal elements in PD, discussed the role of metabolic imbalance of common trace metals (copper, iron, manganese, and zinc) in PD, and put forward new insights into the treatment of PD.