翁佳丽, 李忱菲, 李锋. 臭氧对哮喘和慢性阻塞性肺病的影响及其机制研究进展[J]. 环境与职业医学, 2023, 40(8): 965-971. DOI: 10.11836/JEOM22214
引用本文: 翁佳丽, 李忱菲, 李锋. 臭氧对哮喘和慢性阻塞性肺病的影响及其机制研究进展[J]. 环境与职业医学, 2023, 40(8): 965-971. DOI: 10.11836/JEOM22214
WENG Jiali, LI Chenfei, LI Feng. Advances in research on effects and mechanisms of ozone exposure on asthma and chronic obstructive pulmonary disease[J]. Journal of Environmental and Occupational Medicine, 2023, 40(8): 965-971. DOI: 10.11836/JEOM22214
Citation: WENG Jiali, LI Chenfei, LI Feng. Advances in research on effects and mechanisms of ozone exposure on asthma and chronic obstructive pulmonary disease[J]. Journal of Environmental and Occupational Medicine, 2023, 40(8): 965-971. DOI: 10.11836/JEOM22214

臭氧对哮喘和慢性阻塞性肺病的影响及其机制研究进展

Advances in research on effects and mechanisms of ozone exposure on asthma and chronic obstructive pulmonary disease

  • 摘要:

    臭氧已成为全球主要的环境污染物之一,在空气质量和公众健康领域越来越受到重视。近年来地面臭氧浓度不断升高,对人体呼吸系统和社会经济都造成了沉重负担。众所周知,哮喘和慢性阻塞性肺病(简称慢阻肺)是两种常见的慢性气道疾病。臭氧暴露可诱导慢性气道疾病的发生发展及恶化,短期臭氧诱导非嗜酸性粒细胞哮喘,长期臭氧暴露可诱导慢阻肺,臭氧暴露还可诱导哮喘急性发作,慢阻肺急性加重。其影响主要在于臭氧暴露可介导炎症反应、氧化应激、气道高反应和DNA损伤,并导致肺功能下降、微生物群落改变和气血屏障破坏等健康危害。本综述回顾了近年来臭氧暴露有关哮喘和慢阻肺的一系列流行病学研究和动物实验,并主要归纳了臭氧暴露对气道疾病产生的影响,最后总结了现有研究中存在的不足之处,为进一步研究臭氧暴露对哮喘、慢阻肺的危害和探索新的干预靶点提供有益的方向和思路。

     

    Abstract:

    Ozone has become one of the major global environmental pollutants, and has attracted more and more attention in the field of air quality and public health. Ground-level ozone concentrations have been increasing in recent years, causing serious burden to the human respiratory system and social economy. Asthma and chronic obstructive pulmonary disease (COPD) are two common airway diseases. Ozone exposure can induce the occurrence, development and exacerbation of chronic airway diseases, short-term ozone exposure can induce non eosinophilic asthma, long-term ozone exposure can induce COPD, and ozone exposure can also induce acute attack of asthma and acute exacerbation of COPD. The effects are mainly that ozone exposure can mediate inflammatory response, oxidative stress, airway hyperresponsiveness, and DNA damage, and lead to decreased lung function, changes in microbial communities, and disruption of the air-blood barrier. This paper reviewed a series of epidemiological studies and animal experiments on asthma and COPD related to ozone exposure in recent years, and mainly generalized the effects of ozone exposure on airway diseases. Finally, this paper summarized the shortcomings of existing studies, providing a beneficial direction and ideas for further research on the hazards of ozone exposure on asthma and COPD and for exploring new intervention targets.

     

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