B<i>a</i>P所致神经发育毒性的研究进展

B[a]P所致神经发育毒性的研究进展

基金项目: 国家自然科学基金项目(编号:30800899)

详细信息

摘要

摘要: B[a]P (benzo[a]pyrene,B[a]P)是重要的职业和环境污染物之一,它的神经发育毒性与致癌性\致畸性相比虽是一种弱效应,但会对处于发育中的机体造成不良后果,尤其是中枢神经系统对其更为敏感。本课题组以近年来国内外有关B[a]P神经发育毒性的研究为基础,综述其流行病学研究、实验动物研究以及可能的毒性机制等方面研究进展;结合本课题组的已有研究,认为由于B[a]P的神经发育毒性所致学习和记忆损伤应得到广泛关注。
- B[a]P /
- 神经发育毒性 /
- 认知 /
- 记忆
Abstract: Benzo[a]pyrene (B[a]P) is one of the most important occupational and environmental contaminants. Compared with its carcinogenicity and teratogenicity, its toxicity on neurodevelopment is a weak effect, but could cause serious and adverse consequences for the developing individuals, especially for the central nervous system, which is a very sensitive target. In this paper, based on the research progresses of B[a]P toxicity on neurodevelopment at home and abroad, we summarized the epidemiological studies, neurotoxicity in animal models, and plausible mechanism due to B[a]P exposure. Combined with our previous study, more attention should be paid to the damage to learning and memory by B[a]P exposure.
- benzo[a]pyrene /
- developmental neurotoxicity /
- cognition /
- memory