Abstract:
Objective To investigate the relationship between urinary 1-hydroxypyrene level in pregnant women and scores of Neonatal Behavioral Neurological Assessment(NBNA)in a hospital in Taiyuan, to understand the relationship of the pregnant women exposure to PAHs with physical and behavioral development of their neonates.
Methods High-performance liquid chromatography(HPLC)with subsequent fluorescence detection was used to determine the urinary 1-hydroxypyrene levels in 152 pregnant women who were living in Taiyuan for more than one year, having their babies in the cooperative hospital at the research time and were willing to cooperate with the researchers. NBNA was used to determine the development of neonatal neural behavior. Using MLR(Mutiple Linear regression)to detect the relationship between urinary 1-hydroxypyrene level in the pregnant women and NBNA scores.
Results The median of 152 NBNA scores was 38, in which the NBNA scores of 4 neonates were substandard, less than 35. In multiple linear regression models, there were negative correlations between NBNA scores and urinary 1-hydroxypyrene level, abortion, ages of pregnant women and their husbands, and living near by main traffic roads. There were positive correlations between NBNA scores and number of gestation, and contraception before this gestation.
Conclusion The exposure to PAHs in pregnant women could lead to the reduce of the NBNA scores in their babies. Reducing emission of PAHs to the atmosphere will be significant to physical and behavioral development of neonatus.
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