Abstract:
Objective The toxic effect of neodymium chloride on genetic material of mouse bone marrow cells was explored.
Methods Neodymium chloride was induced to mice via intraperitoneal injection, dose groups were 20, 40, 80, 160 mg/kg for micronucleus test and 20, 40, 80 mg/kg for comet assay. Regular micronucleus test technology and single-cell gel electrophoresis micronucleated erythrocytes were applied on mouse bone marrow samples. Micronucleus and comet tail of DNA cells were calculated.
Results In micronucleus test, micronucleus rates of mouse bone marrow were highly correlated with the doses of neodymium chloride (rFMN=0.956); the cell DNA comet tail ratio and tail length showed dose-response relationships with the doses of neodymium chloride (rPTC=0.946, rTL=0.997, respectively).
Conclusion The study suggested that neodymium chloride may have a genetic toxic effect on marrow cell of mice.
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