Abstract: In recent years, the blood lipid level disturbance resulted from affected lipid metabolism by body iron homeostasis disorders became a research hotspot. As a critical cofactor of many redox enzymes, iron involved in a wide range of biological processes, as well as in oxygen and electron transportation. Lack of iron or excess of iron can result in many diseases. The effects of iro n deficiency and iron overload on lipid metabolism were summarized here.