Abstract:
Objective To observe the effect of Gui-pi decoction on memory function in mice exposed to benzene and explore possible mechanism of Gui-pi decoction in memory function improvement in benzene exposed mice.
Methods Seventy two Kunming mice were randomly selected into 6 groups:the blank control group, the benzene exposure only group, the routine treatment group(Leucosonurn and Batilol) and the Gui-pi decoction groups in three doses(2, 4 and 8 mg/kg& #183;d). Each group contained 12 mice. A Morris water maze systems was applied to study mice behavior. Neuronal morphology and blood tests were also performed.
Results The time of platform navigation and searching in the morris water maze test were significantly lower in the Gui-qi decoction groups than the benzene exposure only group (P<0.01). The number of cross-platform and swimming time in the target zone were significantly lower in the large dose Gui-pi group than in the benzene ezposure only group. The nerve cell morphology and count of hippocampus were significantly different. The hemoglobin were higher in the large and medium dose Gui-pi groups than in the routine treatment group (P<0.05).
Conclusion Gui-pi decoction may improve memory function in benzene exposed mice, which could contributed by improving hematopoiesis and hippocampal neurons function.
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