Abstract:
Objective To study the effect of perfluorooctane sulfonate (PFOS-K)on the liver development in embryo of mice and the toxicity in the embryo.
Methods PFOS-K solution with concentrations of 3mg/kg and 12 mg/kg in a cumulative dose series was infused through gavage into nine-day-pregnant mice. Then, 4 days after the treatment the expression of signal transduction and activators of transcription 3(STAT3) protein in the embryo liver were measured by immunohistochemistry.
Results The expression rates of SATA3 protein in mice with dose 3 mg/kg and 12 mg/kg were 41.62% and 14.77%, respectively. The results showed significant difference (P<0.01).
Conclusion The results showed that PFOS-K could affect the expression amount of STAT3 protein in the embryo liver development. It could be concluded that PFOS-K has certain damage to the liver cell in embryo of mice.
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