Abstract:
Objective To study the infants' basic responses to hepatitis B vaccination and the influencing factors in Qingpu District of Shanghai and probe the responses to re-vaccination of those who showed no or low response in the prior.
Methods With simple random sampling, a total of 677 infants, who were born from February 1, 2008 to March 30, 2009 in Qingpu District of Shanghai and vaccinated with 5μg recombinant beer yeast-derived hepatitis B vaccines (YDVs) or 10μg Hansenula YDVs according to the 0-1-6 immunization schedule, were enrolled as the study subjects. The antibody to hepatitis B surface antigen (anti-HBs) was detected by chemiluminescence microparticle immuno assay. Questionnaires were also employed among the parents to investigate the birth and vaccination course.
Results Of all the 677 infants enrolled, the response rate of the first-course immunity was 82.72%, and the low/non-response rate was 17.28% (2.22% non-response and 15.07% low-response). The group vaccinated with 10μg Hansenula YDVs showed a higher response rate than the group accepted 5 μg beer YDVs. Logistic regression analysis showed a higher response rate in the infants who were female, vaccinated with Hansenula YDVs or full-term (OR=1.529, 3.617 or 9.356, respectively). Among those who showed no or low response after the first course of vaccination, the response rate of the first and the third shots in the second course vaccination were 91.40% and 94.50% respectively. The response rates of the first and the third shots in the second course of vaccination were obviously higher than that in the first course (P < 0.05).
Conclusion The infants who received a full course of the hepatitis B vaccination showed a higher response rate of anti-HBs, but there were still 17.28% of them showed low/nonresponse. Premature birth, low dosage of vaccine inoculated and mothers with positive hepatitis B surface antigen (HBsAg) are the risk factors for low/non-response. Such infants should be re-vaccinated with another 10μg of Hansenula YDVs.
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