Abstract:
Objective To determine the levels of varicella antibody among healthy people less than 15 years old in Songjiang District of Shanghai so as to provide a scientific basis for varicella immunological strategy.
Methods A total of 50 healthy children from scattered homes, kindergartens, primary and middle schools in Songjiang were selected to test varicella immunoglobulin G(IgG) antibodies in their blood using enzyme-linked immunosorbent assay (ELISA) in October 2010.
Results The total positive rate of varicella antibodies among the healthy people less than 15 years old in Songjiang was 66.5%. The average concentration of varicella antibodies was 2 194.9 IU/L. The positive rate of antibodies in children with varicella vaccination history was significantly higher than those without (χ2=13.198, P<0.001), and that in children vaccinated whthin 4 years was significantly higher than those vaccinated before 4 years (χ2=5.457, P=0.019).
Conclusion The varicella antibody levels are low among healthy people less than 15 years old in Songjiang District. So it is recommended to improve the coverage of varicella vaccination among healthy children to establish immunobarrier and also to change immunological strategy to enhance immune persistence.
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