贵州省苗族及布依族人群CYP1A1*2C基因多态性研究

郑波; 黄海燕; 张兵; 王晓梅; 刘建军

贵州省苗族及布依族人群CYP1A1^*2C基因多态性研究

CYP1A1^*2C Gene Polymorphisms in Miao, Buyi Populations of Chinese Guizhou Province

摘要

摘要:
目的检测贵州省苗族及布依族正常人群细胞色素氧化酶1A1^*2C(CYP1A1^*2C)基因多态性。

方法采用Taqman-MGB探针,通过实时定量PCR (real-time PCR)对贵州省三都县125名苗族及122名布依族人群的血液样本进行CYP1A1^*2C基因多态性分析,并采用χ²检验比较两民族该基因分布的差异。

结果 CYP1A1^*2C野生纯合子(基因型AA)、突变杂合子(基因型AG)、突变纯合子(基因型GG)在苗族及布依族中基因型频率分别为65.6%、28.0%、6.4%及68.9%、25.4%、5.7%;A和G在苗族及布依族中基因频率分别为79.6%、20.4%及81.6%、18.4%,两民族人群的基因多态性分布差异无统计学意义。

结论中国贵州省苗族及布依族人群中CYP1A1^*2C基因型频率分布没有明显不同。

Abstract:
Objective To investigate the gene polymorphisms of CYP1A1^*2C in Chinese Miao, Buyi nationalities.

Methods Taqman-MGB probe was used in real-time RealTime-PCR to test the polymorphisms of CYP1A1^*2C in Chinese Miao(125), Buyi(122)people, and the significant difference between Miao and Buyi was checked by χ² test.

Results The distribution of wild homozygote(genetic type AA), mutant heterozygote(genetic type AG), mutant homozygote(genetic type GG)of CYP1A1^*2C in Chinese Miao, Buyi populations were 65.6%, 28.0%, 6.4% and 68.9%, 25.4%, 5.7%, respectively. The distribution of A and G allele frequency of CYP1A1^*2C in Miao, Buyi populations were 79.6%, 20.4% and 81.6%, 18.4%, respectively.

Conclusion The distribution of genetic frequency and allele gene frequency of CYP1A1^*2CC are without statistically significance in difference between Miao, Buyi nationalities in Guizhou Province China.

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贵州省苗族及布依族人群CYP1A1*2C基因多态性研究

CYP1A1*2C Gene Polymorphisms in Miao, Buyi Populations of Chinese Guizhou Province

贵州省苗族及布依族人群CYP1A1^*2C基因多态性研究

CYP1A1^*2C Gene Polymorphisms in Miao, Buyi Populations of Chinese Guizhou Province