Abstract:
Objective To evaluate abnormal glucose metabolism among residents of a community in Pudong New Area in Shanghai, and to study its association with serum C-reactive protein (CRP) levels.
Methods By two-stage cluster randomized sampling, 1 317 community residents aged 35 to 74 years who had lived for at least five years in Gaoqiao Town were selected in 2009. A structured questionnaire was used for interview, and physical examination and biochemical assays were also conducted. Non-parametric Kruskal-Wallis H test, chi-square test, and multinomial logistic model were employed for statistical analysis.
Results The prevalence of diabetes among the selected residents was 12.45%, which was increased with age, and the prevalence of impaired glucose regulation was 12.68%. After adjusted for age, hypertension, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides, the odds ratios for diabetes and impaired glucose regulation in the female residents with CRP ≥ 3 mg/L were 2.510 (95% CI: 1.263-4.987) and 4.335 (95% CI: 2.299-8.172), respectively, with CRP<1 mg/L in the female residents as reference. After further adjusted for body mass index (BMI), the odds ratios were 1.972 (95% CI: 0.972-4.000) and 3.929 (95% CI: 2.055-7.510), respectively, for diabetes and impaired glucose regulation. But the similar association between CRP levels and glycemic status was not found statistically significant in the male residents.
Conclusion The association between different CRP levels and impaired glucose regulation only exist in the selected female residents. After adjusting BMI, the association of different CRP levels with impaired glucose regulation is attenuated, and its association with diabetes is no statistically significant.
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