Abstract: As the development of Shanghai industry, a growing number of new materials and technologies are used, causing more complicated acute occupational poisonings. While the duties of the health authority has adjusted recently, there are new challenges to acute occupational poisoning emergency response. Problems like the lack of occupational hazards monitoring system and uneven distribution of emergency response resources are identified. This article discussed solutions for these problems, such as hazard-oriented monitoring work and integration of emergency response resources.