Abstract:
Objective To study the genetic damages of occupational exposure to Dimethylacetamide (DMAc).
Methods The damages of DNA and chromosomes of peripheral blood lymphocytes were determined by comet assay and cytokinesis-block micronucleus test in exposed group consisting of 30 workers occupationally exposed to DMAc and a control group consisting of 30 workers without exposure to DMAc.
Results In the exposure group, the micronucleus rate, micronucleus cell rate, and nuclei division index were (4.67& #177;2.25)‰(, 4.56& #177;2.19)‰(, 1.82& #177;0.30)‰, and showed no statistical significance of difference between those versus to the control group(5.00& #177;2.62)‰, (4.89& #177;2.59)‰, (1.73& #177;0.25)‰ (P>0.05). The Tail DNA%, mean tail length, and meadians of mean tail moment were(4.76& #177;2.63)%,(12.60& #177;5.68) μm,(2.51& #177;2.30), and showed no statistical significance difference between those to the control group(4.49& #177;2.48)%,(11.77& #177;5.01) μm,(2.28& #177;1.89) (P>0.05).
Conclusion Under condition in this experiment, DMAc occupational exposure exhibited no damage effect on DNA and chromosomes on workers.
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