Abstract:
Objective To investigate the effect of 13q31.1-rs1359790 polymorphism on glycemic control of patients with type 2 diabetes mellitus (T2DM).
Methods A total of 934 Chinese adults diagnosed with T2DM were randomly selected for a baseline survey in Pudong New Area of Shanghai in October 2006. A repetitive survey was carried out in 508 subjects identified in the 2006 survey from September to October 2011. The participants' general characteristics, dietary intake, physical indicators, and level of glycemic control were collected through questionnaires, physical examination, and biochemical tests. Single nucleotide polymorphisms (SNPs) of rs1359790 at 13q31.1 were genotyped by Taqman allelic discrimination assay. Generalized linear model was used to analyze the association between rs1359790 polymorphisms and glycemic control.
Results The genotype frequencies of rs1359790 G/A were AA 0.078, AG 0.404, GG 0.518 and met Hardy-Weinberg equilibrium (P=0.971). The results of the generalized linear model indicated a statistically significant association of rs1359790 polymorphism with the variation of hemoglobin A1c (HbA1c) between the two surveys (P=0.031), after adjusting potential confounding factors. The risk allele G of rs1359790 could reduce the decline of HbA1c level. The intake of dietary fiber was negatively interacted with the effect of rs1359790 polymorphisms on the HbA1c level (P for interaction=0.016). Among the group of low dietary fiber in take, changes in the value of HbA1c levels in the patients with AA+AG genotype were significantly higher than those of the patients with GG genotype (P=0.002).
Conclusion Chromosome 13q31.1-rs1359790 polymorphism affects glycemic control in patients with T2DM, and the effect of fiber intake on their glycemic control can be modified by the polymorphism studied.
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