Abstract: Succimer(DMSA, Di-mercapto-succinic acid)is an antidote against poisoning of broad-spectrum metals. It was first synthesized, studied, and reported by Chinese scientist Dr. Ding Guangsheng 1957, and then being imitated in United States, and approved for marketing by FDA. It was used for treatment intoxication of antimony, mercury, lead, arsenic, other metal poisons, and Wilson's disease. Its application and clinical feature prior to 1990's have been summarized by Dr. Ding Guangsheng in 1989 and 1991. This paper reviews the consequent progression in clinical application and study since then.