Abstract: Occupational acne and occupational melanosis are two common occupational skin diseases, but there are few reports about these two lesions appeared at the same time. This article reported 8 cases of occupational acne with melanosis confirmed at Peking University Third Hospital. The 8 patients came from a same workplace with occupational exposure to anthraquinone, methylene chloride, bromine, dimethylamine and other substances. Skin red papules and pigmentation around pores were distributed over the exposed body parts and occurred 1-6 months after occupational exposure. Occupational acne and occupational melanosis affect skin appearance and psychology of patients, and therefore deserve more attention. At the same time, clinicians should consider whether the skin diseases are caused by occupational factors and warn patients of longer exposure and aggravated lesions.