高原地区公路养护职工机体免疫功能的调查

彭海; 吴世政; 周晶苹; 陈斌; 魏玉香

高原地区公路养护职工机体免疫功能的调查

1.
青海省人民医院, 青海西宁 810007
2. 青海省交通医院, 青海西宁 810000

基金项目: 交通部西部交通建设科技项目(编号:200631800051)

详细信息

作者简介:
彭海(1973-),男,本科,主管检验师;研究方向:临床免疫学、高原医学,E-mail:penghai0000@163.com

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出版历程
- 收稿日期: 2010-02-25
- 刊出日期: 2017-07-18

An Investigation of Immune Functions of Highway Maintainance Workers at Highland Area

1.
People's Hospital of Qinghai Province, Xining, Qinghai 810007, China
2. Qinghai Traffc Hospital, Xining, Qinghai 810000, China

摘要

摘要:
[目的] 了解高原地区公路养护职工的体液免疫、细胞免疫功能及水平。

[方法] 从海拔2 800 m、3 500 m、4 300 m的公路养护区随机抽取194名公路养护工,用免疫速率散射比浊法检测其血清免疫球蛋白G、A、M含量(g/L);用流式细胞术检测其外周血T细胞亚群CD₃⁺、CD₄⁺、CD₈⁺(%)。

[结论] 3组海拔梯度公路养护工的免疫球蛋白G、A含量差异无统计学意义(P>0.05),免疫球蛋白M差异有统计学意义(P<0.01);外周血T细胞亚群CD₃⁺、CD₄⁺、CD₈⁺及CD₄⁺/CD₈⁺的差异有统计学意义(P<0.01)。

[结论] 在高原相对低氧的环境中,公路养护工人的细胞免疫、体液免疫功能有所改变。
- 高原 /
- 免疫球蛋白 /
- T细胞亚群 /
- 公路养护工
Abstract:
[Objective] To investigate the status of humoral immunity and cellular immunity in highway maintainance workers at highland area.

[Methods] A sum of 194 highway maintainance workers working at different altitudes of 2800m, 3500m, and 4 300 m were randomly sampled and investigated. Their serum content of immunoglobulin (Ig)G, A, M (g/L)were determined by immune rate scatter nephelometry, and the frequencies of CD₃⁺, CD₄⁺ and CD₈⁺ T cells in peripheral blood were detected by flow cytometry.

[Results] Although there were no statistically significant differences in the content of IgG and IgA among the three groups (P>0.05), the content of IgM had statistically significant difference (P<0.05)among them. The frequencies of CD₃⁺, CD₄⁺ and CD₈⁺ T cells also showed statistically significant differences among the three groups (P<0.01).

[Conclusion] Working at high altitudes area with lower concentration of oxygen in the ambient air, abnormal humoral immunity and cellular immunity were observed in highway maintainance workers.
- high altitude /
- immunoglobulin /
- T cell subsets /
- highway maintainance workers