Abstract:
Objective To evaluate the genotoxicity of heliotropin.
Methods Genotoxicity of heliotropin was evaluated by the sex-linked recessive lethal (SLRL) test in Drosophila melanogaster and the bone marrow cell micronucleus (MN) test in mice.
Results Compared with the control group, neither the mutation rate nor the micronucleus rate induced by different doses of heliotropin showed significant difference (both P>0.05).
Conclusion This experiment suggests that mutagenesis effect of heliotropin is not supported by the current experimental settings.
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