Abstract:
[Objective] To observe the effect of Saussurea Medusa Maxim (SMM) on immune function of mice with exercise-induced fatigue and discuss the mechanism of its anti-fatigue.
[Methods] Male BALB/c mice were randomly divided into a control group and 2 experiment groups, i.e. the exercise-induced fatigue group and the exercise-induced fatigue+SMM group. The chronic fatigue model was established by exhaustive swimming. Mice in the control group and in the exercise-induced fatigue group were given through gavage with 0.2 mL water while mice in the exercise-induced fatigue+SMM group with 0.1 g Saussurea Medusa Maxim every day for 14 days. The mice in experiment groups received 7 times exhaustive swimming to induce fatigue during the 15 days. On the 15th day, lymphocyte proliferation induced by ConA, plaque forming cell(PFC)and immune organ index were observed.
[Results] After exhaustive swimming, the lymphocyte proliferation induced by ConA, the plaque forming cells and immune organs index in both experiment groups were lower than those in the control group(P<0.01), while those indices in the exercise-induced fatigue+SMM group were higher than those in the exercise-induced fatigue group(P<0.01).
[Conclusion] Saussurea medusa maxim can obviously improve the immune function of mice with exercise-induced fatigue. It has an effect of resisting exercise fatigue.
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