Abstract:
Objective To investigate the effect of baicalin on rat cardiac functions during acute respiratory distress syndrome (ARDS).
Methods A total of 120 rats were divided into three groups:the control group,the ARDS group and the baicalin-treated group.The rats of ARDS group were injected with 0.12 mg/kg of oleic acid through right femoral vein;while in the baicalin-treated group,300 mg/kg of baicalin were given through intraperitoneal injection,and equal volume of saline was administered by peritoneal injection in the control group.Then inserted heparinized catheters into left ventricles,right ventricles and carotid artery of the experimental rats,observe the changes of left ventricular end-systolic pressure (LVSP),+dp/dtmax,-dp/dtmax,right ventricular end-systolic pressure (RVSP),blood pressure by a polygraph and arterial blood gas analysis by a blood-gas Analyzer at 10 min,30 min,1 h,2 h,3 h,6 h,12 h and 24 h after injections,respectively.
Results The level of arterial oxygen partial pressure decreased (P<0.01 vs.control) and met the diagnostic standard of ARDS at 2 hoxygenation index was (189.45& #177;43.03) mmHgin the ARDS group.In baicalin administration group,the level of arterial oxygen partial pressure and oxygenation index were higher than the ARDS group (P<0.01 or P<0.05).Compared with the ARDS group,all the other indices performed in the study were obviously improved in thebaicalin-treated group,such as LVSP,+dp/dtmax,-dp/dtmax,RVSP and blood pressure.
Conclusion Cardiac dysfunction is observed in ARDS,especially right heart dysfunction;baicalin could improve anoxicity and cardiac function in ARDS.
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