Abstract:
Objective To know the difference of toxicity test methods between assessment of chemicals in China and Registration, Evaluation, Authorisation and Restrictions of Chemicals (REACH) of Europe.
Methods According to the different toxicity classification methods, the analysis and comparison were done between instruction for chemicals toxicity identification promulgated by Ministry of Health and methods for the determination of toxicity and other health effects of REACH.
Results The similarities and differences of the methods in our country and REACH were concluded as following:(1)There were little difference between methods of our instruction and REACH, especially they were the same in principle, test system, indicators and judgment end-point. (2)The relatively mature methodologies had been taken in REACH, which had been used for a long time and accepted broadly on Organisation for Economic Co-operation and Development(OECD)criteria.(3)Our instruction was geared to international standards in aspect of technology. But considering the actual testing level, it was essential to make procedures in more details to let our instruction more normal and practicable.
Conclusion The methods used in our instruction are mostly originated from OECD as the same as REACH. So there is little essential difference among the methods. The gap of toxicity test between domestic and aboard is depend on quality control system, the former is not geared to international standards and to set Good Laboratory Practice (GLP)laboratory sustem. So there is lack of comparability on data got from our lab. It is more important to set GLP laboratory used for toxicity testing in China in order to improve the test capability fundamentally.
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