徐佳琳, 胥嘉钰, 贾光. 大气细颗粒物诱发血压升高的分子机制研究进展[J]. 环境与职业医学, 2021, 38(1): 30-36. DOI: 10.13213/j.cnki.jeom.2021.20356
引用本文: 徐佳琳, 胥嘉钰, 贾光. 大气细颗粒物诱发血压升高的分子机制研究进展[J]. 环境与职业医学, 2021, 38(1): 30-36. DOI: 10.13213/j.cnki.jeom.2021.20356
XU Jialin, XU Jiayu, JIA Guang. Advances on potential mechanisms of blood pressure increase induced by ambient fine particulate matters[J]. Journal of Environmental and Occupational Medicine, 2021, 38(1): 30-36. DOI: 10.13213/j.cnki.jeom.2021.20356
Citation: XU Jialin, XU Jiayu, JIA Guang. Advances on potential mechanisms of blood pressure increase induced by ambient fine particulate matters[J]. Journal of Environmental and Occupational Medicine, 2021, 38(1): 30-36. DOI: 10.13213/j.cnki.jeom.2021.20356

大气细颗粒物诱发血压升高的分子机制研究进展

Advances on potential mechanisms of blood pressure increase induced by ambient fine particulate matters

  • 摘要: 高血压作为最常见的心血管疾病之一,是我国慢病防治的重中之重。大气细颗粒物(PM2.5)是多种心血管疾病的危险因素。在PM2.5影响血压的机制中,氧化应激和炎症反应发挥着关键性作用。PM2.5的理化成分包括炭黑、有机物、无机离子和金属等,不同理化成分可以激发不同炎症通路,从多个途径影响血压调控。本综述总结PM2.5影响血压的分子机制,并着重介绍PM2.5中不同组分在调控血压中发挥的作用,以期为空气污染诱发高血压的防治问题提供理论依据和研究思路。

     

    Abstract: As one of the most common cardiovascular diseases, hypertension is the top priority of chronic diseases prevention and control in China. Ambient fine particulate matter (PM2.5) is a risk factor for multiple cardiovascular diseases. In reported mechanisms by which PM2.5 affects blood pressure, oxidative stress and inflammation play key roles. The components of PM2.5 include black carbon, organic matters, inorganic ions, and metals, and they can stimulate different inflammatory pathways and affect blood pressure regulation in varied ways. This review summarized the potential molecular mechanisms of PM2.5 affecting blood pressure, and focused on the roles of different components of PM2.5 in regulating blood pressure, aiming to provide a theoretical basis and research ideas for the prevention and treatment of hypertension induced by air pollution.

     

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