生命早期双酚A暴露对子代神经发育影响的研究进展
Review on effects of bisphenol A exposure in early life on neurodevelopment of offspring
-
摘要:
双酚A（BPA）是工业上一种重要的化学品，用于制造许多产品，如工程塑料、食品容器、运动器械、电子产品、眼镜镜片、牙科复合材料和密封剂等。从1992年开始生产至今，中国对BPA的需求和生产能力迅速增长，已成为世界最大的生产国。BPA在大部分地区的环境介质中及人体内均可检出，它被认为是一种内分泌干扰化合物，生命早期BPA暴露对子代神经发育的影响已经引起了广泛关注。动物实验阐述了BPA暴露对子代神经行为和认知能力产生不良影响的生物学可能性，主要表现为多动及侵袭性、焦虑样行为，其空间学习能力及记忆能力下降。目前的人群研究中所得到的结论并不完全一致，大部分研究提示生命早期BPA暴露与子代神经情绪行为发育问题和认知发育问题有关，主要表现为焦虑、多动、抑郁、外化行为、反抗行为、躯体化行为、工作记忆能力降低等。我国相关研究仍然缺乏，未来应继续探究BPA对子代神经发育的影响及作用机制，以便针对易感人群如孕妇和儿童等制定更好的防护措施。
Abstract: Bisphenol A (BPA) is an important chemical in the manufacture of products such as engineering plastics, food containers, sports equipment, electronics, eyeglass lenses, dental composites, and sealants. Since the first production in 1992, China has shown rapid growth in the demand and production capacity of BPA, becoming the largest producer in the world. As an endocrine disrupting compound, BPA has been detected in most environment mediums and human body, and its impact of early life exposure on the neurodevelopment of offspring has caused worldwide concern. Animal experiments have demonstrated the biological possibility of adverse effects of BPA exposure on behavior and cognition, including hyperactive, invasive, and anxiety-like behaviors, as well as decreased spatial learning ability and memory ability. However, inconsistent conclusions are obtained in population-based epidemiologic studies, most of which suggest that early-life exposure to BPA is adversely associated with the development of neuroemotional behaviors and cognitive function in the offspring, such as anxiety, hyperactivity, depression, externalization, resistance, and somatic behaviors, as well as reduced working memory ability. Relevant research is scarce in China; therefore, further studies need to explore the impact and mechanism of BPA on children's neurodevelopment, aiming to develop better protective measures for vulnerable populations such as pregnant women and children.
下载:
