环境内分泌干扰物的女性生殖毒性及其在妇科肿瘤发生发展中的作用
Female reproductive toxicity of environmental endocrine disruptors and their roles in development and progression of gynecological tumors
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摘要:
环境内分泌干扰物是一类广泛存在于环境中，进入机体后可以干扰机体内分泌系统和天然激素的功能，进而导致器官损害和疾病发生的外源性物质或混合物。近年来，乳腺癌、卵巢癌、子宫内膜癌等女性雌激素依赖性肿瘤发病率逐年增加。研究表明，环境内分泌干扰物对女性生殖系统具有毒性作用，且环境内分泌干扰物的暴露可以增加激素敏感性器官的肿瘤发生率。本文就环境内分泌干扰物中具有代表性的三类物质邻苯二甲酸酯（PAEs）、多氯联苯（PCBs）和双酚A（BPA）对生殖系统的影响及其在妇科肿瘤发生发展中的作用进行综述，以期为预防妇科肿瘤、环境内分泌干扰物的毒作用研究及污染防控提供依据。
Abstract: Environmental endocrine disruptors (EEDs) refer to a class of exogenous substances or their mixtures widely present in environment that are known to interfere with human endocrine system and the function of natural hormones, leading to organ/tissue damage and diseases. In recent years, there are evident increasing incidences of female estrogen-dependent tumors such as breast cancer, ovarian cancer, and endometrial cancer. A great number of studies indicate that exposure to EEDs is toxic to female reproductive system and one of the underlying etiological factors for developing tumors in hormone-sensitive organs. This paper systematically reviewed phthalates (PAEs), polychlorinated biphenyls (PCBs), and bisphenol A (BPA) about their effects on female reproductive system and their implications in developing gynecological tumors, aiming to provide evidence for further studying gynecological tumor prevention, EEDs toxicity, and pollution prevention and control.
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