Abstract:
Objective To study the association between ABCG2 gene polymorphisms and hyperuricemia susceptibility in Xinjiang Uygur population.
Methods A case-control study was conducted in 1 024 Uygur hyperuricemia patients and 1 033 healthy controls. Sequenom Mass ARRAY®SNP technique was used to detect the polymorphisms of ABCG2 gene in the subjects, including rs117104615, rs1448784, rs2231137, rs2231142, rs2622621, and rs2622626. Single nucleotide polymorphisms (SNPs) associated with the susceptibility to the disease were identified by genetic model analysis.
Results When comparing the genotypes and alleles of six loci of ABCG2 gene between the hyperuricemia group and the control group, the risk of hyperuricemia was higher in the subjects carrying CA (OR=1.586, 95%CI:1.305-1.929) and AA (OR=1.807, 95%CI:1.171-2.788) genotypes of rs2231142 locus; the risk was also higher in those carrying A allele (OR=1.505, 95%CI:1.284-1.763). The G allele at rs2622626 locus was a protective factor for hyperuricemia, and was associated with a lower risk of hyperuricemia (OR=0.861, 95%CI:0.759-0.977). In the dominant model of rs2231142 adjusted for selected covariances (age, sex, smoking, etc.), CC was a protective factor in the Uygur population (OR=0.562, 95%CI:0.468-0.676, P < 0.05). In the recessive model of rs2622626, GT and TT genotypes increased the risk of hyperuricemia (OR=1.312, 95%CI:1.026-1.676).
Conclusion SNPs at rs2622626 and rs2231142 loci of ABCG2 gene may be associated with susceptibility to hyperuricemia in Uygurs.
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