全氟辛烷磺酸的表观遗传学作用研究进展

Research progress on epigenetic effects induced by perfluorooctane sulfonate

摘要: 全氟辛烷磺酸（PFOS）广泛应用于食品包装材料、纺织用品、纸张、杀虫剂的生产。PFOS具有高持久性、生物蓄积性和潜在致癌性质，能对生态环境和人体健康造成严重的危害，其毒性作用受到广泛关注。本文主要从DNA甲基化、组蛋白修饰、非编码RNA调控3个方面，综述PFOS对机体的表观遗传学作用。

Abstract: perfluorooctane sulfonate (PFOS) is widely used in food package, textile, paper, and insecticide. The toxic action of PFOS has attracted increasing attention due to its high persistence, bioaccumulation, potential carcinogenicity, and consequently great harm to ecological environment and human health. This review focused on the epigenetic effects of PFOS on DNA methylation, histone modification, and non-coding RNA regulation.