Abstract:
Objective To investigate the effects of occupational stress and ADD1 gene on the prevalence of hypertension in Karamay oilfield workers.
Methods A total of 1 300 oilfield workers in Karamay were selected by random cluster sampling method and investigated using Occupational Stress Inventory-Revised (the number of valid questionnaire was 1 233, and the valid rate was 94.8%). Blood samples were collected from 352 oilfield workers (176 hypertension cases and 176 controls) to extract DNA and detect the genotypes of rs17833172 and rs4961 in ADD1 gene by polymerase chain reaction-restrictive fragment length polymorphism method.
Results There was a higher score of occupational role in Karamay oilfield workers (168.28±34.19) than that of the domestic norm (162.89±27.04) (P < 0.05). The prevalence rate of hypertension increased with higher occupational stress levels (χtrend2=13.82, P < 0.05), and the prevalence rate was higher in the high-stress group (18.49%) than in the low-stress group (1.54%) and the middlestress group (5.51%). Among the blood samples of 352 oilfield workers, the genotypes of rs4961 varied among groups categorized by gender, age, and working years between the hypertension case group and the control group (Ps < 0.05). The multi-factor logistic regression analysis results showed that higher personal coping resources (OR=0.989, 95%CI:0.979-0.998) and TT genotype of rs4961 (OR=0.455, 95%CI:0.244-0.846) were protective factors for hypertension, while GG genotype of rs17833172 (OR=3.113, 95%CI:1.402-6.916) was a risk factor (P < 0.05).
Conclusion Oilfield workers' hypertension may result from multi-sourced pathogens related to genes or occupational stress. Higher personal coping resources and rs4961 TT genotype of ADD1 gene may associate with a lower risk of hypertension in the oilfield workers, while rs17833172 GG genotype may associate with a higher risk of hypertension.
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