Abstract:
Objective To assess the relationship between occupational exposure to wood dust and lung cancer.
Methods Studies were identified through CNKI, VIP, Wanfang data, Pubmed, Science Direct, Wiley Online Library, Web of Science and Google Scholar, and the theme words included "wood dust, " "hardwood dust, " "softwood dust, " "saw dust, " "lung cancer, " "lung carcinoma, " and "lung malignancy, " in both Chinese and English. Studies were included according to inclusion and exclusion criteria. Heterogeneity test, combined effect value, and publication bias were carried out with I 2 statistics, fixed effect model, and Egger test method using Stata 12.0 software respectively.
Results Seventeen papers reporting occupational exposure to wood dust and lung cancer were included. An increased risk of lu ng cancer was associated with occupational exposure to wood dust (unadjusted OR=1.61, 95%CI:1.46-1.78; adjusted OR=1.49, 95%CI:1.33-1.65). The highest risk of occupational exposure to wood dust was found in the category of other lung cancer (OR=1.48, 95%CI:1.19-1.84), followed by squamous cell carcinoma (OR=1.43, 95%CI:1.16-1.75), and adenocarcinoma (OR=1.29, 95%CI:1.06-1.57). The Funnel plot and Egger test results showed no publication bias in this study.
Conclusion Occupational exposure to wood dust might increase the risk of lung cancer.
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